All books are in clear copy here, and all files are secure so dont worry about it. Laboratory tests may show slight changes in the electroencephalogram. In a kls cohort followed in a single center, patients regularly took lithium carbonate median dose 1,000 mgday. Kleine levin syndrome foundation genetic and rare diseases. Csf hypocretin1 levels in narcolepsy, kleinelevin syndrome. Associated features of the disorder include a lack of concentration, mood changes, and anxiety. Kleine levin syndrome kls is a rare disorder characterised, most notably, by periodic episodes of hypersomnolence and hyperphagia. Kleine levin syndrome kls is a sleep disorder that is characterized by recurring episodes of excessive sleep. In this paper, we report the very first two cases observed in the. Migraine with brainstem aura has not previously been widely considered in the medical literature as a differential diagnosis. Kleinelevin syndrome is a rare disorder that primarily affects adolescent males approximately 70 percent of those with kleinelevin syndrome are male. Nature and science of sleep dovepress kls foundation.
Kleinelevin syndrome more details kls is a rare disease characterized by recurrent episodes of hypersomnia and to various degrees, behavioral or cognitive disturbances, compulsive eating behavior, and hypersexuality. Kleinelevin syndrome definition of kleinelevin syndrome. We selected the color silver to represent the silver lining of hope, happiness, health, wealth, and love we believe all kls sufferers deserve. Patients often undergo multiple investigations to rule out other causes of encephalopathy. More detailed information about the symptoms, causes, and treatments of kleinelevin syndrome is available below symptoms of kleinelevin syndrome. Kleine levin syndrome, sometimes referred to as rip van winkle disease, is a rare sleep disorder mainly affecting teenage boys in which the main features are intermittent hypersomnolence.
Jodys kleine levin syndrome was featured on tlc in october 2017, sorry about the poor quality, it is recorded via a phone off the television, but we wanted to share the video to enable a wider. For language access assistance, contact the ncats public information officer. The change of episode duration with ivmp vs previous episode duration was. In this paper, we report the very first two cases observed in. To compare the benefits and risks of lithium therapy vs abstentionother treatments in kleine levin syndrome kls. Kleinelevin syndrome kls is a rare sleep disorder characterized by. Learn about kleinelevin syndrome, a disorder characterized by recurring episodes of excessive sleep up to 20 hours per day. Kleinelevin syndrome is a recurrent hypersomnia associated with symptoms of hyperphagia, hypersexuality, and cognitive impairment. Recurrent hypersomnia, or kleinelevin syndrome, is rare and frequently causes substantial diagnostic anxiety and delay. Hunger, fixation on sex, and sleeping in are normal among teenage boys.
Forgotten diseases research foundation kleinelevin. Kleinelevin syndrome pdf calendar and kls awareness bands. Affected individuals may sleep for up to 20 hours per day during an episode. Kleine levin syndrome genetic and rare diseases information. Kleinelevin syndrome kls kleinelevin syndrome kls is a chronic sleep disorder and is one of the central disorders of hypersomnolence cdhs. There was a possible reduction in frequency with lithium treatment, however. Kleinelevin syndrome kls is a sleep disorder that is characterized by recurring episodes of excessive sleep. Genetic and rare diseases information center gard po box 8126, gaithersburg, md 208988126 toll free.
Kleinelevin syndrome is rare, affecting an estimated 15 per million individuals. Kleine levin syndrome kls is a rare disorder that causes recurring periods of excessive sleepiness. This term refers to conditions that cause excessive daytime sleepiness, meaning that patients have trouble staying awake during the day 1. Kleine levin syndrome kls foundationss first international conference.
Kleinelevin syndrome, hypersomnia, adolescent sleep disorder. Because its primary symptom, hypersomnia, is common to a number of disorders, the process by which we diagnose kls is one of exclusion ruling out other conditions that share symptoms. In most cases, patients sleep 15 to 21 hours a day during episodes. Kleinelevin syndrome kleinelevin syndrome treatment. Kleinelevin syndrome kls, also called recurrent hypersomnia, is a rare sleep disorder characterized by recurrent episodes of severe hypersomnia associated with cognitive and behavioral disturbances such as confusion, derealization, apathy, compulsive eating, and hypersexuality. It is a disease predominantly of teenagers, and boys are four times more likely to be affected than girls. Kleinelevin syndrome, sometimes referred to as rip van winkle disease, is a rare sleep disorder mainly affecting teenage boys in which the main features are intermittent hypersomnolence, behavioural and cognitive disturbances, hyperphagia and in some cases hypersexuality.
There is no specific, definitive treatment to cure or control kls. Kleine levin syndrome is a complex medical disorder that causes recurring periods of excessive drowsiness and sleep up to 20 hours per day. Kleine levin syndrome kls is a chronic sleep disorder and is one of the central disorders of hypersomnolence cdhs. Diagnosing kls is admittedly a challenge but can be a relief for a family in search of answers. However, clinical presentation and laboratory tests are normal during asymptomatic intervals. It is characterized by relapsingremitting episodes of severe hypersomnia, cognitive impairment, apathy, derealization, and psychiatric and behavioural disturbances, which last usually 1 to 4 weeks arnulf et al.
To determine the role of csf hypocretin1 in narcolepsy with and without cataplexy, kleinelevin syndrome kls, idiopathic and other hypersomnias, and several neurological conditions. Kleinelevin syndrome is a rare cause of hypersomnia characterised by a recurrent alteration of sleepwake regulation and frequent abnormal feeding and sexual behaviours. Kleine levin syndrome is a rare disorder characterized by relapsingremitting episodes of hypersomnia, cognitive disturbances, and behavioral disturbances, such as hyperphagia and hypersexuality. The kls is a rare neurological and sleep disorder in the hypersomnia family that mainly affects. One of the ways you can help change that is by printing out the kls brochure and sharing it with your community, friends, family, and health care professionals. Jul 10, 2017 kleine levin syndrome is a rare disorder characterized by recurrent episodes of excessive sleep hypersomnia along with cognitive and behavioral changes. This term refers to conditions that cause excessive daytime sleepiness, meaning.
The change of episode duration with ivmp vs previous episode. Kleinelevin syndrome diagnosis, causes, treatment tuck sleep. Kleinelevin syndrome nord national organization for rare. Ideal sources for wikipedias health content are defined in the guideline wikipedia. The trip database provides clinical publications about. Here are links to possibly useful sources of information about kleinelevin syndrome. Some aspects of the disease can be managed with medication, such as stimulants to combat the eds, but this is most effective only once the episodes have already decreased in severity. Alexandria virginia sleep specialist doctors physician directory learn about kleinelevin syndrome, a disorder characterized by recurring episodes of excessive sleep up to 20 hours per day. The kleine levin syndrome, first described by kleine 1 in 1925 and levin 2 in 1929, is composed of recurring episodes of sleepiness lasting days, associated with excessive appetite and often with abnormal behavior. Kleinelevin syndrome diagnosis stanford health care. Kleinelevin syndrome is a recurrent hypersomnia associated with symptoms of.
But when these behaviors are extreme, it may be the kleinelevin syndrome kls, or what some have dubbed the sleeping beauty syndrome. Learn about kleine levin syndrome, a disorder characterized by recurring episodes of excessive sleep up to 20 hours per day. Kleinelevin syndrome is a rare, sporadic disorder, with discrete spells of. Iv steroids during long episodes of kleinelevin syndrome. Many patients also experience hyperphagia, hypersexuality and other symptoms. This latter functionality led us to use this treatment in our kls patient. Kls is a rare and complex neurological disorder characterized by recurring periods of excessive amounts of sleep, altered behavior, and a reduced understanding of the world where the patient becomes progressively drowsy and sleeps for most of the day and night, sometimes waking only to eat or use the bathroom. With only two cases per million, kleinelevin syndrome is a rare neurological disorder that mainly affects adolescents. Treatments for kleinelevin syndrome stanford health care. Kleinelevin syndrome is a rare disorder characterized by the need for excessive amounts of sleep hypersomnolence, i. Kleinelevin hibernation syndrome, familial kleinelevin syndrome, familial hibernation syndrome. Alexandria virginia sleep specialist doctors physician directory learn about kleine levin syndrome, a disorder characterized by recurring episodes of excessive sleep up to 20 hours per day.
Jun 27, 2010 kleine levin syndrome kls is a rare sleep disorder mainly affecting teenage boys in which the main features are intermittent hypersomnolence, behavioral and cognitive disturbances, hyperphagia, and in some cases hypersexuality. Kleinelevin syndrome information page national institute. Kleinelevin syndrome, sometimes referred to as rip van winkle disease, is a rare sleep disorder mainly affecting teenage boys in which the main features are intermittent hypersomnolence. Kleinelevin syndrome symptoms, diagnosis, treatments and. These serious episodes alternate with periods without any symptoms. However, clinical presentation and laboratory tests are normal during. Kleinelevin syndrome is one of those rare disorders of function of the brain whose. Kleinelevin syndrome was first described by kleine in 1925 and elaborated on by levin in 1936, but it was critchley and hoffman who further defined the syndrome in 1942 and gave it its eponym. Pdf kleinelevin syndrome kls is a rare disorder with symptoms that include. A clinical diagnosis of kleinelevin syndrome kls was made, and he was started on carbamazepine at 400 mg per day, on which he remained event free for a period of 2 years. K leine levin syndrome kls is a sleep disorder of unknown etiology characterized by episodic hypersomnia, hyperphagia, cognitive and mood abnormalities, and abnormal behaviors. Kleinelevin syndrome kls is rare, but is still the most common form of recurrent hypersomnia with a prevalence of 12 per million. Most often an affliction that affects adolescent males, the episodes may come out of nowhere and affect your loved one for a few days or a few weeks.
In some cases, this means up to 20 hours a day are spent sleeping. Kleine levin syndrome is a rare disorder that primarily affects adolescent males approximately 70 percent of those with kleine levin syndrome are male. These episodes usually last for a few days to a few weeks. Kleinelevin syndrome nord national organization for. Kleine levin syndrome kls, also called recurrent hypersomnia, is a rare sleep disorder characterized by recurrent episodes of severe hypersomnia associated with cognitive and behavioral disturbances such as confusion, derealization, apathy, compulsive eating, and hypersexuality. Kleinelevin syndrome kls is a rare disorder characterized by periodic hypersomnia associated with behavioural disturbances such as binge eating hyperphagia, irritability, and increased sexual interest hyper sexuality. Kleinelevin syndrome kls is a rare disorder characterised, most notably, by periodic episodes of hypersomnolence and hyperphagia. Kleinelevin syndrome kls is a rare sleep disorder mainly affecting teenage. Kleine levin syndrome is a rare disorder characterized by recurrent episodes of excessive sleep hypersomnia along with cognitive and behavioral changes. Kleinelevin syndrome kls is a rare sleep disorder characterized by recurrent and unusually long episodes of hypersomnia, associated with behavioralcognitive disturbances, megaphagia and more rarely sexual disinhibition. Request pdf kleinelevin syndrome kleinelevin syndrome is a rare recurrent hypersomnia associated with symptoms of behavioral and cognitive impairment. Associated symptoms include an abnormally uninhibited sex drive, irritability, and disorientation. To compare the benefits and risks of lithium therapy vs abstentionother treatments in kleinelevin syndrome kls. Kleine levin syndrome is a rare disorder characterized by the need for excessive amounts of sleep hypersomnolence, i.
Apr 24, 2018 objective to retrospectively compare the benefits episode cessation and risks of iv methylprednisolone ivmp vs abstention during prolonged kleine levin syndrome kls episodes. The kleinelevin syndrome, first described by kleine1 in 1925 and levin2 in 1929, is composed of recurring episodes of sleepiness lasting days, associated with excessive appetite and often with abnormal behavior. Each episode lasts for one or two weeks, and affected people are entirely asymptomatic between episodes. Methods a total of 26 patients with kls received 1 gd ivmp for 3 days during 1 to 6 episodes each totaling 43 ivmp sessions. When you wear the kls wrist band out and about, it helps start conversations with others about kls which in turn spreads the word. This is your chance to help spread the word about kls by wearing the kleinelevin syndrome wrist band. The kleinelevin syndrome is a differential diagnosis for patients with diurnal excessive sleepiness and a suspicion of narcolepsy.
The kleinelevin syndrome is a rare pathology characterized by recurrent episodes of hypersomnia associated with behavioral and cognitive disorders with, among others, hyperphagia and hypersexuality. If you have problems viewing pdf files, download the latest version of adobe reader. Jan 20, 2014 kleine levin syndrome is a recurrent hypersomnia associated with symptoms of hyperphagia, hypersexuality, and cognitive impairment. Kleinelevin syndrome kls is a rare sleep disorder characterized by persistent episodic hypersomnia and cognitive or mood changes. Kleinelevin syndrome kls is a rare sleep disorder mainly. For this reason, the condition is commonly referred to as sleeping beauty syndrome. Symptoms may last for days to weeks, include excessive food intake, lack of energy, disorientation, irritability, and sensitivity to noise. It is rare for patients over the age of 30 years to present with their first. Kls can also produce changes in behavior and confusion.
Kleinelevin syndrome kls is a rare neurological disorder of unknown origin. Home about us rare disesases global growth curves calculators contact donate. Kleinelevin syndrome kls is rare, but is still the most common form of. Recurrent hypersomnia, or kleine levin syndrome, is rare and frequently causes substantial diagnostic anxiety and delay. Kleinelevin syndrome is a rare neurological disorder characterized by recurring periods of excessive amounts of sleep and altered behavior. Kleinelevin syndrome is a complex medical disorder that causes recurring periods of excessive drowsiness and sleep up to 20 hours per day. Gerardi, ma,1joseph casadonte, md,2,3 priyal patel, ba,1 and tanya k. The relationship between the two syndromes, the praderwilli syndrome and the kleinesyndrome, deserves further study. Med interdisziplinar 14 tage kostenlos testen keine printzeitschrift enthalten.
Gard po box 8126, gaithersburg, md 208988126 toll free. This site is like a library, you could find million book here by using search box in the. Although no populationbased studies reporting on kls prevalence are available, it is generally considered an. Kleinelevin syndrome does not affect me or a close family member. We collected detailed clinical data and blood samples on 108 patients, 79 parent pairs, and 108 matched control subjects. Pdf kleinelevin syndrome kls is the commonest recurrent sleep disorder with. The disease predominantly affects adolescent males. Kleinelevin syndrome kls is a rare disorder that causes recurring periods of excessive sleepiness. Mar 27, 2019 kleine levin syndrome is a rare disorder that primarily affects adolescent males approximately 70 percent of those with kleine levin syndrome are male. Symptoms occur as episodes, typically lasting a few days to a few weeks. In my 1993 publication abnormal fluctuations of acetylcholine and serotonin medical hypotheses vol. Patients with kleine levin syndrome kls experience recurring episodes of prolonged sleep hypersomnia. The kleine levin syndrome is a rare pathology characterized by recurrent episodes of hypersomnia associated with behavioral and cognitive disorders with, among others, hyperphagia and hypersexuality.
The kleine levin syndrome kls bands are a way to spread awareness and remember those who suffer with kls. It is characterized by paroxysmal attacks of diurnal excessive sleepiness, associated with one or more symptoms of hyperphagia, hypersexuality, coprolalia and copropraxia. Objective to retrospectively compare the benefits episode cessation and risks of iv methylprednisolone ivmp vs abstention during prolonged kleinelevin syndrome kls episodes. It is characterized by recurring but reversible periods of excessive sleep up to 20 hours per day.
14 544 777 476 477 1015 521 1035 1000 1403 25 213 95 558 982 191 739 1459 421 1137 1356 780 956 945 924 221 310 371 1401 424 692 96 1108 1196